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KMID : 0644319980040010071
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Journal of Korean Oriental Oncology
1998 Volume.4 No. 1 p.71 ~ p.87
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Effects of Gunleetang Gagambang Extract on Antitumoral Immunological Response and the Side Effect Induced by Antitumoral Agents
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유경태/Yui, Guyng-Tea
문석재/문구/원진희/Moon, Suk-Jae/Moon, Goo/Won, Jin-Hee
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Abstract
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Even though appropriate immune response is necessary for the survival of the individual, excessive or insufficient immune Response might cause autoimmune of allergic disease, So the immune response must be controlled to the degree. that is beneficial for the well being of the individual. This study was undertaken to know the effects of Gunleetang Gagambang on the immune system of the mouse.
Gunteelane Gagambang has been used for cure of tumor as a traditional medicine without any experimental evidence to support the rational basis for its clinical use. This study was carried out to evaluated the possible therapeutic or antitumoral effects of Gunleetang Gagamvang extract against tumor, and to carry out some mechanisms responsible for its effect.
Some kinds of tumor were induced by the typical application of 3-mehtylcholanthrene(MCA) or by the implantation(S.C) of malignant tumor cells such as leukemia cells(3LL cells) or sarcoma cells(SI80 cells). Treatment of the Gunleetang Gagamvang on water-extract(dailly lmg/mouse, i. p.) was continued for 7 days prior to tumor induction and after that the treatment was lasted for 20 days. Against squamous cell carcinoma induced by MCA, Gunleetang Gagambang decreased not only the frequency of tumor production but also the number and the weight of tumors per tumor bearing mice(TBM). Gunleetang Gagamvang on also significantly suppressed the development of 3LL cell and SI80 cell-implanted tumors in occutence=frequency and their size, and some developed tumors were regressed by the continuous treatment of Gunleetang Gagambang extract into TBM. In vitro, treatment of Gunleetang Gagambang also stimulated the migrative ability of leukocyte, the MIF and IL.
2. production of T lymphocytes, but not IL 6 production of B cells. Gunleetang Gagamvang administration to mice enhanced NK cells activities.
These results demonstrated that Gunleetang Gagabang extrat exhibited a significant prophylactic benefits against tumors and its antitumor activity was manitested depending on the type of tumor cells. And these results also suggested that effect of Gunleetang Gagambang might be chiefly due to nonspccific enhancement of NK cell activities and cell-mediated immune responses.
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KEYWORD
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